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What is Tramadol Tramadol can be used in both its immediate-release and extended-release form. Immediate-release Tramadol starts to work within about an hour and lasts for about four to six hours. Extended-release Tramadol works to steadily deliver the drug over a longer period of time, usually between 12-24 hours. Tramadol can also be compounded into different dosages and taken with acetaminophen to get a stronger analgesic effect.     Don't Miss Out on Our Exclusive Online Tramadol Sale - Shop Now! Uses of Tra... more