Whenever you create a new character in Diablo II: Resurrected (D2:R), you will have the option to select the Hardcore option, which can be selected at any point during the character creation process. This field is left blank by default in order to prevent spamming of the system. The only time this box should be checked is if you are seriously considering taking part in Hardcore. Once your character has been created, there is no way to change the mode in which you are playing.
Some of the distinctions between non-Hardcore and Hardc...
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