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The best time to take Pain O Soma 500 or any other muscle relaxant medication typically depends on when you experience the most discomfort or muscle spasms. However, it's essential to follow your healthcare provider's instructions regarding dosage and timing. In general, muscle relaxants like Pain O Soma 500 are often taken three to four times daily, with or without food. It's essential to spread out the doses evenly throughout the day to maintain a steady level of the medication in your system and ensure consistent r... more