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Ambien is a powerful sedative, also called a hypnotic. Ambien is commonly used to treat sleep problems in adults with acute insomnia.

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Zolpidem is an analog of benzodiazepines yet not a benzodiazepine fundamentally, but a hypnotic drug from the group of so-called Z drugs, with an imidazopyridine structure that makes it like that of the previous. It follows up on a similar benzodiazepine receptor and a similar dynamic focal point of the chlorine channel. Dissimilar to these, Zolpidem doesn't have impacts at the spinal level since it doesn't tie to the receptors there.


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Two Frenchmen developed the Ambien molecule, the Paris-born biochemist Jean-Pierre Kaplan and George Pascal, another young French biochemist. Zolpidem was launched in 1988 by the French pharmaceutical multinational, Synthélabo, now Sanofi.

In 1992 Synthélabo, in conjunction with the Pfizer subsidiary, Searle, was brought to the United States. Finally, it was not until 2007 that Ambien became available as a generic drug.

In 2015, the American Geriatrics Society said that Zolpidem, eszopiclone, and zaleplon met the Beers standards and should be kept away from people 65 and over.

The AGS expressed the strength of the proposal that older adults avoid Zolpidem is "strong," and the quality of evidence supporting it is "moderate."


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