If you are pregnant, take Provigil without first seeing your doctor because its effects on fetuses are unknown. To guarantee the safe use of Provigil, it is imperative to disclose any history of mental illness, psychosis, or alcohol/drug addiction. Dopamine release from Provigil doesn't appear to increase significantly, which may help explain why it has a lower risk of abuse and dependence. Provigil ability to impact other neurotransmitters like histamine and norepinephrine precisely is what also helps it to promote wakefulness.