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What is OxycodoneOxycodoneis an opioid medicine available for the management of moderate to severe pain. It is an oral medication in both immediate-release and extended-release formulations. Oxycodone’s onset of action typically begins within 15 minutes, and effects wear off in about six hours for immediate-release forms. People can also buy oxycodone onlinein combination with acetaminophen or aspirin.
Oxycodone is more potent than morphine as studies show that 5 mg of oxycodone has roughly 1.5 times the effectiveness of 5 mg morphine.
Germans first made oxycodone from thebaine in the year 1916. In the United States, the medication is also available as a generic version with a wholesale cost of less than $0.30 per pill.
Oxycodone is one of the most prescribed opioid analgesics in the United States, with more than 10 million prescriptions per year.
Uses of OxycodoneYou can buy oxycodone onlinefor managing your pain conditions ranging from moderate to severe acute or chronic pain. Doctors prescribe oxycodone only when other treatment options such as combination opioids or non-opioid analgesics are not sufficient for a patient to provide required pain relief. The medication may also improve the quality of life in certain conditions.
Adverse EffectsOxycodone produces several side effects along with its needed healing impact. People should buy oxycodone onlineonly on a doctor’s prescription. Severe side effects of the medication include reduced sensitivity to pain, anxiolysis, euphoria, feelings of relaxation, and respiratory depression.
Some common adverse effects of oxycodone include:
Nausea (23%)
Constipation (23%)
Somnolence (23%)
Itching (13%)
Dizziness (13%)
Vomiting (12%)
Dry mouth (6%)
Sweating (5%)
Less common oxycodone side effects experienced by less than 5 % of patients include nervousness, loss of appetite, diarrhea, abdominal pain, dyspnea, urine retention, and hiccups.
Most of the adverse effects become less severe over time and gradually go away in a few days or within a week. However, constipation is more likely to continue throughout use.
InteractionsThe medication interacts with many drugs to produce unwanted effects. It is advisable to buy oxycodone online and read the label instructions to know about all its potential drug interactions.
Enzymes such as CYP3A4 and CYP2D6 metabolize oxycodone. So, the inhibitors and inducers of these enzymes can alter the clearance of oxycodone by increasing and decreasing the medication’s half-life, respectively. Genetic variations in these enzymes also influence the removal of oxycodone, which relates to the wide inter-person variability in its potency and half-life.
Lopinavir/ritonavir or ritonavir significantly increase oxycodone’s plasma concentrations in healthy humans due to inhibition of CYP2D6 and CYP3A4.
Rifampicin reduces oxycodone’s plasma concentration due to its active CYP3A4 inducing property. In a chronic pain patient, fosphenytoin, an inducer of CYP2A4, dramatically reduces the analgesic effects of oxycodone.
It is necessary for a doctor to adjust the dosages or medications in case of drug interactions.
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