Insomnia occurs when a person either has difficulty falling asleep, or wakes repeatedly during the night. Taking Ambien or a similar drug allows the brain and body to relax. And at its most basic level, Ambien works by slowing activity in the brain. Ambien (zolpidem) is a sedative, also called a hypnotic. Zolpidem affects chemicals in the brain that may be unbalanced in people with sleep problems insomnia). Ambien is used to treat insomnia. The immediate-release tablet is used to help you fall asleep when you first go to bed. The extended-release form, Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep. Ambien may impair your thinking or reactions. You may still feel sleepy the morning after taking this medicine, especially if you take the extended-release tablet, or if you are a woman. Wait at least 4 hours or until you are fully awake before you do anything that requires you to be awake and alert. Zolpidem cause a severe allergic reaction. The recommended initial doses for women and men are different because zolpidem clearance is lower in women.
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Learn about medication Ambien. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. The total dose of Ambien should not exceed 10 mg once daily immediately before bedtime. Ambien should be taken as a single dose and should not be readministered during the same night.
Ambien is a brand (trade) name of zolpidem. Zolpidem causes sedative effects by enhancing the effects of GABA, a chemical transmitter in the brain. However, zolpidem's chemical structure is different from benzodiazepines. Clinicians prescribe zolpidem for short-term (usually about two to six weeks) treatment of insomnia. Zolpidem addresses sleep-initiation problems, but is not effective in maintaining sleep. Also, a 2012 NIH study showed that zolpidem's effectiveness is nearly as much due to psychological effects as to the drug itself, so increased attention should be directed at psychological intervention of insomnia. Zolpidem has some muscle relaxant and anticonvulsant properties, but has not been approved for use in muscle relaxation or seizure prevention. This is because the dosage of drug needed to cause muscle relaxation is 10 times the sedating dose, while early studies indicated that the dosage needed for preventing seizures is 20 times the sedating dose.
How Ambien WorksAmbien works incredibly fast. It hits peak blood concentrations only 30 minutes after being ingested. Because of the rapid onset of effects, it's important that Ambien be taken immediately before going to bed, and not earlier in the day. It's such a strong sedative that it's dangerous to attempt to drive or perform physically-demanding activities while on Ambien. How much Ambien can you take at once is limited to 10 mg zolpidem at night, before sleeping.
Ambien is a central nervous system depressant. This means it slows brain activity. Most central nervous system depressants affect the brain in the same way - they enhance the activity of gamma-aminobutyric acid, a naturally occurring chemical in the brain that sends messages between cells (neurotransmitter). GABA works by slowing down brain activity. Although different classes of CNS depressants work in unique ways, they ultimately increase GABA activity, which produces a drowsy or calming effect.
Ambien side effectsAmbien can also have disturbing side effects. In some people, it causes memory problems, and can even cause people to act out everyday activities in their sleep, including driving, cooking, or having sex. Obviously, this is a very dangerous side effect and Ambien should be discontinued immediately if you suspect you're engaging in any activities in your sleep. And Ambien should not be taken along with other central nervous system depressants, such as alcohol, benzodiazepines, or even antihistamines. In fact, mixing alcohol and Ambien is never recommended and many doctors will ask that you avoid drinking while taking Ambien. Ambien can cause excessive drowsiness and become dangerous when mixed with other medications.
Ambien is not right for everyone. In fact, Ambien is a habit-forming medication that's not recommended for those with a history of drug or alcohol abuse. And in some people Ambien can cause severe side effects or dangerous behaviors. People who experience problems while taking Ambien should talk to their doctor immediately about discontinuing the medication.
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