Etizolam belongs to a new class of diazepines, thienotriazolodiazepines. This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has an anxiolytic action about 6 times greater than that of diazepam. Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time and a reduction in the number of awakenings. During tests there were not substantial changes in deep sleep. There is a reduction of REM sleep. In tests, Etizolam showed some characteristics of tricyclic antidepressants. Etizolam (marketed under the brand name Etilaam, Etizola, Sedekopan, Pasaden or Depas) is a thienodiazepine drug which is a benzodiazepine analog. It possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
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Initially introduced in 1983 in Japan as treatment for neurological conditions such as anxiety and sleep disorders, etizolam is marketed in Japan, Italy and India. It is not approved for use by FDA in the US; however it remains unscheduled in several states and is legal for research purposes. The dependence and abuse potential of benzodiazepines is well recognized. This has resulted in the search for novel anxiolytics devoid of such potential. Etizolam is a thienodiazepine anxiolytic and is said to have low tolerance and dependence liability than benzodiazepines.
Effects of EtizolamThis medicine acts on benzodiazepine receptors and relieves anxiety and tension. It also has the effect to relieve muscle tension. It is usually used to improve anxiety, tension, depression sleep disorder caused by neurosis, depression and psychosomatic disorder (hypertension, gastroduodenal ulcer). It is also used to improve muscle stiffness, etc. caused by cervical spondylosis, low back pain and muscle-contraction headache. Etizolam is a CNS depressant with anxiolytic, anticonvulsant, sedative-hypnotic and muscle relaxant effects. Studies indicate that etizolam mediates its pharmacological actions with 6 to 10 times more potency than that of diazepam. Clinical studies showed effectiveness of etizolam in relieving symptoms in patients with generalized anxiety disorders with depressive symptoms. The average elimination half life of etizolam following a single oral dose of 0.5mg is 3-4 hours.
Etizolam PropertiesThis drug is a thienodiazepine, which is very similar to a benzodiazepine in its effects and composition. It produces euphoric and sedative effects. Etizolam usually comes in pill form. It is small, round, blue and has a line down the middle. Etizolam is marketed under several brand names from different pharmaceutical manufacturers. Etilaam, Arophalm, Capsafe, Depas, Dezolam, Eticalm, Etidrale, Etisedan, Etizolan, Guperies, Medipeace, Mozun, Nonnerv, Palgin, Pasaden, Sedekopan, Sylazepam. Most are based in India.
Etizolam for Pain ReliefEtizolam is a substance that has properties of analgesia, and it can be used for pain relief. Also, Etizolam is known to act as a sedative. Sedating a patient with pain also relieves his condition.
As stated earlier that Etizolam can be used for pain. It can be used for alleviating chronic pain. It can be taken by patients to relieve the pain associated with cancer chemotherapy. It also helps patients with post-operative pain. It is useful for fibromyalgia, osteoarthritis, rheumatoid arthritis, fractures and other painful diseases like colic, etc.
DependenceThe claim of low dependence potential of etizolam has led to it being prescribed liberally in the markets where it is available for a long time, like Japan. This myth is being realized now after it has become the most frequently prescribed benzodiazepine there. Perhaps, this is the reason for its nonavailability in developed markets of United States of America and Europe. It was approved for use in India and perhaps because of late entry, remains one of the least used benzodiazepine in India. However, the literature about its abuse and dependence potential is sparse. The rapid relief of anxiety by ultra-short-action and feeling of anxiety after the action wears off may lead to dependence by both positive and negative behavioral reinforcement. This case report highlights the fact that the same caution be applied while prescribing etizolam with respect to dependence potential as for any other benzodiazepine. In the case of development of dependence, treatment of the primary disorder, substitution with longer-acting benzodiazepines, Selective Serotonin Reuptake Inhibitors and psychotherapy are various options that can be exercised.
Dosing scheduleHow to take Etizolam?
For neurosis and depression: In general, for adults, take 2 tablets (1 mg of the active ingredient) at a time, 3 times a day.
For psychosomatic disorder, cervical spondylosis, low back pain and muscle-contraction headache: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time, 3 times a day.
For sleep disorder: In general, for adults, take 2 to 6 tablets (1 mg to 3 mg of the active ingredient) at a time, once a day before bedtime.
In any case, the dosage may be adjusted according to your disease, age and symptoms. For elderly patients, the maximum daily dose is 3 tablets (1.5 mg of the active ingredient). Strictly follow the instructions.
If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. You should never take two doses at one time. If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. Do not stop taking this medicine unless your doctor instructs you to do so.
Etizolam is an anxiolytic, a hypnotic and a sedative substance that also alleviates pain.
The normal dosage that can be given for relieving pain is 0.5mg to 1.0 mg, but the dosage can be increased to 2 mg if the pain is too intense or crushing. The dosage of an Etizolam for pain relief must not be increased above 2.0 mg.
Increased frequency of Etizolam intake and increased dosage can result in side effects.
Experiences of patients related to Etizolam as an analgesicAccording to many patients, they have used Etizolam for anxiety or depression and surprisingly found out the amazing analgesic effects of Etizolam. For them, a nightmare ended because now they didn't have to take two medications. Many patients, however, do not discuss the analgesic properties of Etizolam. They are more inclined towards the anxiolytic and anti-depressant effects of Etizolam. According to them the analgesic effect of Etizolam is due to the sedation produced by taking a larger dose of Etizolam.
What does research say about the use of Etizolam for pain?
At recent research study it was that the painful symptoms of irritable bowel syndrome disappeared in patients who were given Etizolam. In most of the patients, the pain was reduced, and the number of bowel motions was decreased, concluding that Etizolam is effective in patients with colon disorders. Another study included patients who suffered from a tension headache. The results of the study predicted that the combination treatment of NSAIDs and Etizolam proved to be more useful in patients having a tension headache.
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This medicine may cause drowsiness and decreased attention/concentration/reflex movement. Avoid operating dangerous machinery, such as driving a car. Pay attention when drinking alcohol, since it may intensify medicinal effects. The drug must not be consumed for over a period of four weeks or more, or it develops a habit of habituation or addiction. The medicine tends to show lesser effective with time if taken continuously for more than a month. Consuming Etizolam by patients suffering from liver and kidney problem is dangerous. Inform the doctor prior if you are consuming the drug during your pregnancy or planning to conceive.
Possible adverse reactionsMajor side effects effects include drowsiness, sedation, muscle weakness and incoordination, fainting, headache, confusion, depression, slurred speech, visual disturbances and changes in libido and tremor.
The most commonly reported adverse reactions include drowsiness, light headedness, malaise, lassitude, rash, hives, itch and erythema. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
unable to control addiction to the medicine, convulsion, insomnia, anxiety (dependence)
general malaise, loss of appetite, yellowing of the skin and the white of eyes (liver dysfunction, jaundice)
fever, muscle stiffness, tremor in limbs (malignant syndrome)
muscle pain in limbs, numbness, lassitude, reddish brown urine (rhabdomyolysis)
fever, dry cough, respiratory distress (interstitial pneumonia)
Since etizolam is not controlled or regulated, it can be purchased by anyone to conduct legal chemical research. Why should you buy Etizolam online from online drugstore? In Japan, India and Italy, Etizolam is a legal drug that is prescribed by doctors. People who do not live in these countries can buy etizolam only from online pharmacy. Quality and sevrvice is paramount. Usually, once you place your order, they guarantee the product to your door - or your money back. For more information, please always check pharmacy shipping page. As a rule Etizolam comes packaged by one of the the major India pharmaceutical company. India is the world's capital for quality medicines, be it pharmaceutical formulations, herbal medicines or nutraceuticals. Their Pharma Division deals only with the best, GMP certified generics and branded medication for the export market. All their products are supported by strict adherence to quality and analysis certification. So Etizolam is sourced directly from the manufacturer so that there is no compromise on the drug quality. This also means that the drug is low priced.
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Etizolam is a wonder substance that has a range of properties. According to user experiences and scientific experimentation, Etizolam is a potent analgesic that can be used for various painful conditions. However, its main use is found in the treatment of anxiety and insomnia. If the careful dosage of Etizolam is taken it can prove to be very effective.
